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These mutations can lead to the loss of mitochondrial proteins, defects in respiratory chain complexes, and impaired oxidative phosphorylation

Specifically, TST downregulation leads to decreased S-sulfhydration of very long-chain specific acyl-CoA dehydrogenase (VLCAD), an enzyme essential for mitochondrial FAO

Peptide-derivatized biodegradable nanoparticles able to cross the bloodbrain barrier

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10.1128/jvi.74.24.11782-11791.2000 318 ZimmerB.EwaleifohO.HarschnitzO.LeeY.PeneauC.McAlpineJ

It follows logically that addressing multiple mechanisms simultaneously through carefully selected peptide combinations could produce outcomes exceeding what any single peptide achieves alone