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Excessive TNF in the brain is linked to neurodegenerative diseases, cognitive dysfunction, and possibly long Covid/ME/CFS.[ref][ref][ref][ref][ref] Related article : TNF-alpha: Genetic variants that increase inflammation Acute vs

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Benzyl isothiocyanate inhibits invasion and induces apoptosis via reducing S100A4 expression and increases PUMA expression in oral squamous cell carcinoma cells

The results demonstrated that conditioned medium from MPP+-treated microglia substantially induced neuronal apoptosis and impaired cellular viability, whereas conditioned medium from irisin-treated microglia significantly reduced neuronal apoptosis and enhanced cell survival (Fig

I think its a really good paradigm shift to start moving away from this mentality of oversimplified idea of, if you have a SNP, that means your methylation is not working, then you add these things, these methyl donors, and it fixes the problem