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4.2 Relationship between tau protein and ferroptosis in AD 4.2.1 Relationship between abnormal tau phosphorylation and ferroptosis in AD Iron overload-induced lipid peroxidation promotes Tau polymerization, leading to hyperphosphorylation and NFT formation in the brain (Ayton et al., 2000)

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Ma Q, Hao S, Hong W, Tergaonkar V, Sethi G, Tian Y, Duan C

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A significant positive correlation was observed between NOS3 and IRE1 ( r = 0.19, p = 2.27e-06), BiP ( r = 0.11, p = 5.82e-03), PDI ( r = 0.20, p = 3.59e-07), XBP1 ( r = 0.13, p = 1.67e-03), PERK ( r = 0.21, p = 1.51e-07), and CHOP ( r = 0.19, p = 2.71e-06) in the Decipher GRID dataset (Fig