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Increasing p62 levels was sufficient to recreate the molecular and behavioral profiles of Bdnf +/ mice
Side effects are usually minor and short-lived

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Overexpression of wild-type STUB1 , but not of a catalytically inactive mutant, leads to reduced BMAL1 protein levels, confirming its role in regulating BMAL1 stability through K48-linked polyubiquitination and proteasomal degradation (Ullah et al., 2020)
