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Functionally, MCS represents an adaptive attempt to preserve core cell functionsincluding proliferation, differentiation, migration, secretion, neuronal signaling, and muscle contractionand, under pathological conditions, to sustain pro-inflammatory activity [187,190]

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Finally, senescent skin cells die by a mechanism that is either described as apoptosis or autophagic programmed cell death [337,338]

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Because of its stable structure, it supports investigations into biological signaling pathways, angiogenesis, and recovery-related mechanisms

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