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CuP demonstrates a wide range of biological activities, including antioxidative properties, inflammatory modulation, chemotactic cell recruitment, and promotion of angiogenesis and cell proliferation 35,36

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However, neither of these drugs has improved OA symptoms in human clinical trials to date, likely because of the dynamic joint environment

Author contributions PG designed the study and led the analysis

Venetz, D

This approach utilizes computational technology to begin with the biological characteristics of diseases, identify the optimal nanomaterials through material-biological interactions, material-property relationships, and appropriate ligands or adjuvants, simulate the construction of ideal nanomedicines, and accurately analyze their physicochemical properties