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Specifically, overexpression of catalase in CAR-T cells improved tumour killing of an ovarian cancer cell line under oxidative stress, while TRX1 overexpression enhanced pro-inflammatory cytokine production, proliferation, and cytotoxicity against a breast cancer cell line in oxidative conditions (31, 128)

Med Res Rev 39(6):25052533 Losada-Barreiro S, Sezgin-Bayindir Z, Paiva-Martins F, Bravo-Daz C (2022) Biochemistry of antioxidants: mechanisms and pharmaceutical applications

Potassium channels in peripheral pain pathways: Expression, function and therapeutic potential

Funct Integr Genomics 25 , 213 (2025)

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Hassan E, Leslie J