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Circulating MOTS-c declines with age and tracks with insulin resistance, making it both a potential longevity biomarker and a therapeutic target

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Immunofluorescence staining All cells on the sections were fixed with 4% paraformaldehyde, followed by washing three times in PBS and blocking with 5% BSA

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229, 238, 245, 246 Of 26 total patients, 20 (77%) had complete pain relief and one was moderately improved