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Vascular and microvascular manifestations: Raynaudphenomenon, digital ulceration, or sclerodactyly reflect vascularand microvascularrelated involvement in systemic sclerosis and some lupusrelated phenotypes, raising concern for progressive fibrosis and organsystem compromise

[DOI] [PubMed] [Google Scholar] 20.Arangia A., Marino Y., Fusco R., Siracusa R., Cordaro M., DAmico R., Macr F., Raffone E., Impellizzeri D., Cuzzocrea S., et al

10.1074/mcp.m114.041384 Mol

Finally, when considering gut irritation and alcohol consumption, there is the issue of bloating, gas, and general digestive discomfort