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238,239 Senescent macrophages in the eyes secrete proinflammatory cytokines via STAT3 signaling, aggravating retinal damage and promoting neovascularization, a hallmark of AMD

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Consecutive reactions of the radicals with a thiolate anion and molecular oxygen lead to disulfide and superoxide radicals formation [102]

doi: 10.1007/s12640-021-00362-w, 112

In addition, other signaling pathways, such as the mTOR pathway and the unfolded protein response (UPR), can also regulate autophagy and ferroptosis in cancer cells through feedback mechanisms [88, 89]