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A phase I study assessed the feasibility and safety of cellular immunotherapy using ex vivo expanded autologous memory-enriched T cells, genetically modified with a self-inactivating (SIN) lentiviral vector to express a HER2-specific, hinge-optimized, 41BB-costimulatory CAR, as well as a truncated human CD19 (HER2[EQ]BBzeta/CD19t+), for participants with recurrent/refractory malignant glioma

10.1021/tx700031r 77 SivilottiM

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