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Among the proteins significantly down-regulated in untreated diseased plants are those associated with the activity of oxidoreductase, glutathione transferase, and superoxide dismutase ( Supplementary Table 3 )

The significance of HER2 in CRC arises from its ability to promote cell proliferation and transformation through the activation of downstream signaling pathways, as well as its role in inducing resistance to anti-EGFR agents, ultimately resulting in a poorer prognosis for patients [17, 21,22,23,24,25]

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Safety concerns remain because unapproved BPC-157 products can vary in purity, strength, and sterility

The fact that BAK1 is endocytosed together with PEPR1 raises the possibility that the BAK1-PEPR1 receptor complex maintains signaling from endosomes (Supplemental Figure 11)

This work was supported by the Japan Agency for Medical Research and Development (AMED) under grant number DNW-15006 and and Grant-in-Aid for Scientific Research (B), and (C) from the Japan Society for the Promotion of Science (#20H03788, #23K20328, #22K06921)