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Macrophages detect endogenous danger signals present in necrotic cell debris via toll-like receptors (TLRs), intracellular pattern recognition receptors, and interleukin-1 receptor (IL-1R), most of which are conducted via the adaptor molecule myeloid differentiation primary response gene 88(MyD 88)

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doi: 10.1016/j.rbmo.2020.03.020