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J Biol Chem 273:3216732175
Precisely, this happens via oxidation of Fe 2+ ion in heme, after which Fe 2+ is reduced by reaction with H 2 O 2
Science 328 , 321326 (2010)
In one study, Fe 3+ -coordinated croconaine nanoparticle encapsulated with bovine serum albumin (Cro-Fe@BSA) was designed for combined photothermal and ferroptosis cancer therapy
AGEs can stimulate NADPH oxidase and the unregulated production of superoxide radicals (O 2 ) in mitochondria [89,90]
1, 3, 4 Here, a pivotal role is played by mitochondria as an intracellular source of ROS
