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Withanoside and Somniferine have been shown by molecular docking and dynamic stimulation to exhibit a high binding affinity for SARS-CoV-2 main protease enzyme (Mpro) with high binding affinity and have therapeutic potential against COVID-19 (Shree et al., 2022)

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The bottom line on human data: promising signals, no randomized controlled trials, and no long-term safety data in humans

Tolerance development : Effects diminish over time, requiring higher doses