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Level of Evidence: 3 Thermodynamically stable ionic liquid microemulsions pioneer pathways for topical delivery and peptide application Type of study: non-rct in vitro Number of citations: 10 Year: 2023 Authors: Tian-Hu Liu, Ying Liu, Xiaoyu Zhao, Liguo Zhang, Wei Wang, De Bai, Y
The per-oral application (0.16 g/mL/rat/day or 0.16 ng/mL/rat/day continuously in drinking water) began on day 14 and continued till sacrifice
Although it does not appear to interact with the gut microbiota directly, evidence suggests that the vagus nerve can sense microbial signals in the form of bacterial metabolites, or be influenced via microbiota-mediated modulation of enteroendocrine (EECs) and enterochromaffin (ECCs) cells in the gut epithelium 86 (Figure 2)
Understanding these levels helps guide dietary choices or supplementation needs
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