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Experimental evidence supports these findings, where PHGDH knockdown reduces cellular D -2HG levels by 50% in PHGDH-overexpressing breast cancers, while overexpression increases D -2HG levels by 2-fold compared to wild-type PHGDH ( de novo biosynthesis, whereas knockdown significantly impairs proliferation, even in the presence of extracellular serine

Regulatory immune T cells are responsible for maintaining immune tolerance of homeostatic gut microbiota (Wu and Wu, 2012)

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The pivotal human work used oral dosing