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Another point of interest regarding B12 supplementation is the commonly held belief that intramuscularinjections of B12 are more effective than oral supplementation

in contrast, chronic or constitutive Nrf2 overactivation due to somatic KEAP1/NFE2L2 mutations, epigenetic maladjustment, or persistent pharmacologic stimulation may be used to nourish tumor progression, chemoresistance, metabolic reprogramming and immune-evasive phenotypes in established cancers [15, 393, 394], [83]

Fletcher M, Ramirez ME, Sierra RA, Raber P, Thevenot P, Al-Khami AA, et al