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Reasons why mitochondria might be impaired or damaged include: Aging Inadequate diet Poor sleep Lack of exercise Genetics Heavy and toxic metals Pollutants Free radicals Prescription drugs Alcohol There are many conditions that are caused or made worse by mitochondrial dysfunction, such as the following per Pizzorno (2014): Early aging Amyotrophic lateral sclerosis Alzheimers disease Autism Cardiovascular disease Chronic fatigue syndrome Dementia Diabetes Huntingtons disease Migraine headache Parkinsons disease A great way to directly influence the health of our mitochondria is through the use of peptides

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SLU-PP-332 is frequently discussed as a potent but non-selective ERR agonist with strongest activity reported at ERR in vitro, making it a useful tool for comparative receptor studies and pathway mapping