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Another study found that iron deposition in the frontal lobe, parietal lobe, temporal lobe, caudate nucleus, putamen, globus pallidus, cingulate cortex, amygdala, and hippocampus of AD patients was higher than that of healthy controls (Tao et al., 2014), and histological differences in the intensity of iron accumulation in the frontal cortex of AD subtypes can be used not only to distinguish sporadic (late-onset) from familial (early-onset) (Bulk et al., 2018a), but also to correlate with disease severity (van Duijn et al., 2017
