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Nagy's group also confirmed that different thioredoxins (Trx1 and TRP14) could reduce protein-bound perthiosulfonate (Dka et al., 2020)

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The lack of pore opening under these conditions is consistent with the low open probability of KARs 66 in the absence of PAMs and the partial activation observed with 5-IW (Fig

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One study reported a 10fold range of baseline ascorbate values in their participants, from deficient to saturating concentrations [25], which is a limitation as Cmax values correlate with baseline ascorbate concentrations [23]