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By scavenging excessive ROS, polysaccharides can prevent the activation of pro-tumorigenic pathways (e.g., NF-B and MAPK) that are driven by oxidative stress (136)

Additionally, GBM maintains an immunosuppressive local microenvironment through a variety of signaling pathways, including the release of immunosuppressive cytokines (e.g., IL-6), the expression of immune checkpoint molecules (e.g., PD-L1), TGF-B signaling, and the expression of STAT3 [25,26,27,28,29,30]

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This injury disrupts the brain's normal communication pathways and can cause significant neurological deficits

ROS: reactive oxygen species

Cellular Protection : By neutralizing reactive oxygen species (ROS) and free radicals, glutathione protects cells from oxidative damage and maintains cellular integrity