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They damage any proteins they come into contact with and the accumulation or build-up of these radicals and the damage they create causes oxidation (modifications to your proteins, lipids and DNA.) [1] An example of how free radicals could harm skin cells is a condition called idiopathic guttatehypomelanosis
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Amft N, Curnow SJ, Scheel-Toellner D, Devadas A, Oates J, Crocker J, et al

Iversen SD, Howells RB, Hughes RP (1980) Behavioral consequences of long-term treatment with neuroleptic drugs

In addition to drug combinations, the synergistic potential of curcumin with other natural substances, including resveratrol, quercetin, and piperine, has also been well investigated

Signal Transduct Target Ther 9(1):55
