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Disrupting melanosome transport may also induce autophagy-mediated degradation of accumulating melanosomes, which can contribute to the decrease of melanin content in cells [126]

When exposed to stress, these membranes undergo significant alterations, particularly in the compositions of sterols vital compounds responsible for membrane permeability, fluidity, transmission of stress signals, the function of membrane-associated enzymes, and proton pumps [13]

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While having megaloblastic anemia, hyperhomocysteinemia, and/or neuropathy are not medical conditions that influence vitamin B12 absorption, they are clearly indications for the use of vitamin B12 supplements when deficiency is established

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