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A personalized treatment plan considers: medical history current medications injury type treatment goals overall health factors Proper guidance helps support safe and appropriate use

Standard dose escalation schedule Clinical trials established the dose escalation approach that minimizes gastrointestinal side effects while achieving therapeutic levels

However, receptor desensitization can occur with prolonged use, reducing effectiveness

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(2) dissociation of tumor cells from the primary tumor mass, (3) invasion of the neighboring tissue, (4) intravasation into pre-existing and newly formed blood and lymph vessels, (5) transport through the vessels, (6) extravasation from the vessels, (7) establishment of circulating tumor cells (CTCs) and the disseminated cells at a secondary anatomical site, where they can stay dormant for a prolonged period of time, (8) metastatic outgrowth of micrometastases and macrometastases creating clinically detectable secondary tumors and neoplastic process [13]