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Mitochondria and NMDA receptor-dependent toxicity of berberine sensitizes neurons to glutamate and rotenone injury

Journal of Research in Medical Sciences , 17(12), 11611169

Conclusion This study reveals significant metabolic alterations in congenital hypothyroid patients, including reduced long-chain acylcarnitine levels and inferred low CPT-I activity, which are suggestive of impaired -oxidation and energy metabolism

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The primary functions of FC and acylcarnitines (AC), mainly acetyl-L-carnitine (ALC) in humans, are the transport of long-chain fatty acids (FAs) to the mitochondrial matrix and maintaining the mitochondrial homeostasis of coenzyme A (CoA) during mitochondrial oxidation of these acids [49]