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To date, clinical trials of single-agent anti-IGF-1R mAbs and IGF-1R TKIs have been disappointing, reporting low objective response rates and with only minor responses and disease stabilization in most tumor types (Table 1) [58, 59, 62, 81,82,83,84,85,86,87,88,89,90,91,92,93,94,95,96]