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The studies involving animals were reviewed and approved by the Ethics Committee on Animal Use (CEUA-NPDM/UFC: #37270922-0)

(-)-Epigallocatechin-3-gallate Reduces Cigarette Smoke-Induced Airway Neutrophilic Inflammation and Mucin Hypersecretion in Rats

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One of its core mechanisms lies in the activation of the AMPK/PGC-1 signaling pathway

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Both UK-5099 and -cyano-4-hydroxy cinnamate have been reported to also inhibit the monocarboxylate transporters found at the plasma membrane and therefore potentially cellular pyruvate uptake
