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If your goal aligns with the goals of published research (consistent NAD+ elevation, reproducible metabolic effects, dose-response clarity), the administration route that achieves those goals is injection

And even though hydroxocobalamin (another synthetic form of B12) is generally well-tolerated, this prescription form of injectable B12 has been associated with certain side effects such as: Nausea Vomiting Diarrhea Headaches Dizziness Hot flushes Pain or redness at the injection site There have also been some reported reactions in people who are sensitive to hydroxocobalamin