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Among these, OCTN2 is the most important physiologically transporter of carnitine due to its high affinity and wide expression (27)

L-Carnitine is a natural amino acid supplement designed to support energy production, fat metabolism, and overall vitality

A six-month study using 2g/day found substantial decreases in HbA1c (-0.623) and triglycerides (-31.39) [31]

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Similarly, dietary approaches that increase NO precursors or mitigate oxidative stress (such as dietary nitrate, CIT/L-arginine, and antioxidant polyphenols) can improve exercise-induced enhancements in endothelial function and microvascular blood flow, thereby augmenting substrate delivery to trained musculature and enhancing training responsiveness in geriatric populations (81)

Chronic inflammation promotes neuropathology, including accelerated brain aging, increased risk of developing psychiatric disorders, and cognitive decline 85