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Glutathione plays a major role in many chemical reactions in the body

ROS might act as a signaling molecule and activate the antioxidant proteins by interacting with signaling partners such as respiratory burst oxidase homolog (RBOH), G-proteins, Ca2+, mitogen activated protein kinases (MAPKs), and various transcription factors (TFs)

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Finally, this review systematically summarizes therapeutic interventions targeting ROS homeostasis

Cytotoxicity of heavy metals in the human small intestinal epithelial cell line I-407: the role of glutathione