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Second, the doses are small because the target is a high-affinity intracellular enzyme, not a receptor that needs saturating with milligrams of drug

Daneshvar N, Salari D, Khataee AR (2004) Photocatalytic degradation of Azo dye acid red 14 in water on ZnO as an alternative catalyst to TiO 2

TAAR1 & Activation of NET/DAT/SERT Reverse Transport: Nature's Homeostatic Safety Valve Under baseline physiological conditions, catecholamines (like dopamine and norepinephrine) are kept sequestered at extremely low levels in the presynaptic cytoplasm (representing only ~3% of the total terminal contents), with the vast majority safely packaged in acidic storage vesicles (Hussain et al., 2023)
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