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10.1074/jbc.M300084200 126 MassotteD

Moreover, disruption of mitochondrial quality control pathways, including impaired mitophagy due to PINK1 or Parkin dysfunction, exacerbates oxidative injury and contributes to neuronal vulnerability [58, 189]

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As you age and are exposed to more metabolic stressors, you can move to 1000mg daily

10.1016/S0891-5849(03)00275-2 [DOI] [PubMed] [Google Scholar] Favrin G., Bean D.M., Bilsland E., Boyer H., Fischer B.E., Russell S., Crowther D.C., Baylis H.A., Oliver S.G., and Giannakou M.E

Human skeletal muscle transcriptomics As stated in the original paper reporting these data [17], the study protocol conformed to the ethical guidelines of the 1975 declaration of Helsinki and had received an a priori approval by the Ethical committee of Karolinska Institutet, Stockholm, Sweden and local ethics approval for gene expression analysis at Heriot-Watt University, Edinburgh, Scotland