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The binding of CDT to TLR2 and TLR4 receptors on macrophages may also induce the secretion of chemokine (C-X-C motif) ligand 2 (CXCL2) and TNF- [225]

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It enhances atherosclerosis, promotes thrombosis potential, vascular inflammation and inflammasome activation [17]
Van Dyken P, Lacoste B (2018) Impact of metabolic syndrome on Neuroinflammation and the bloodbrain barrier

These data show that additional melanocyte markers (such as SOX10) are useful when faced within this differential diagnosis (melanoma vs malignant peripheral nerve sheath tumor), but may be insufficient in some situations (particularly in desmoplastic melanomas)

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