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By blocking NNMT, it shifts intracellular NAD+ and S-adenosylmethionine (SAM) levels, two cofactors tied to energy metabolism, redox balance, and gene regulation in laboratory models

Regional fat-loss effects: Research suggests AOD9604 may be especially effective at reducing visceral adipose tissue (VAT), the fat stored around internal organs

The result is a vicious cycle where declining NAD+ leads to worse metabolic function, which can lead to weight gain, which increases NNMT activity further

and stopping injections