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These are mediated by 11-hydroxylase (P450c11 or CYP11B1), which generates cortisol (followed by activities of the ER enzymes P450c21 and P450c17), and aldosterone synthase (P450c11AS or CYP11B2) which produces aldosterone 91,92,93,94

doi: 10.1016/j.pbb.2011.05.002

Reactive oxygen species (ROS) are generated through interaction of the excited state chromophore with a variety of substrates, which go on to oxidatively damage biomolecules (37)