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doi:10.1016/j.jacl.2024.08.013 Tsimikas, S., Karwatowska-Prokopczuk, E., Gouni-Berthold, I., Tardif, J

While many people get enough vitamin B12 naturally from their diets, vegetarians and vegans will often need a supplement because they eat little or no animal protein

Hierarchy of Evidence: Level D (Pre-clinical animal models)

This leads to activation of a Ca 2+ -dependent nitric oxide synthase, which generates nitric oxide, which acts as a retrograde messenger by diffusing back to presynaptic neurons

Both promote tissue repair, but they work through completely different mechanisms which is why many researchers study them together