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In patients without anemia, cyanosis first appears at methemoglobin concentrations of about 15%

The role of cellular senescence in female reproductive aging and the potential for senotherapeutic interventions

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PLoS ONE 8 , e69062 (2013)

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It functions as a critical component of the cellular antioxidant defense system, participating in detoxification reactions, protein folding, and redox homeostasis