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Her predicted creatinine clearance is 22 mL/min (Cockcroft & Gault), so for digoxin, her renal clearance is 6 22/100 60/70 = 1.1 L/h, nonrenal clearance 2.7 60/70 = 2.6 L/h, and total clearance 3.7 L/h

p75NTR is a neurotrophin receptor, which can induce different cellular responses, including cell growth but also apoptosis

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