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Meanwhile, 14-3-3, a negative regulator of the cell cycle, becomes impaired, leading to increased keratinocyte proliferation [49]

Meng M, Huang M, Liu C, Wang J, Ren W, Cui S, et al

194, 195 Whether this constitutes an off-target mechanism of resistance or rather reflects the inhibition of caspase-9 by AKT1-transduced signals 196 (hence representing a post-target effect) remains to be clarified

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Neurotrophic Activity and Its Modulation by Zinc Ion of a Dimeric Peptide Mimicking the Brain-Derived Neurotrophic Factor N-Terminal Region