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With respect to structural outcomes, the guideline development group regarded measurement of joint space narrowing as of questionable value in assessing any potential beneficial structural modification, and convincing evidence of improvement in patient-centred outcomes consequent on any structural modification was still lacking

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The delayed disease has features resembling those of mucosal disease of cattle, which is considered to be caused by superinfection by a different strain of BVDV or by minor mutation of homologous virus in animals that are persistently infected