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Changes in viscosity, either thickening or unusual thinning, indicate formulation instability
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The FDA will hold a PCAC meeting July 23-24 to give recommendations on 7 peptides
Derivation of the PNEC The PNEC is based on toxicological experiments with species in the laboratory, where the concentration-effect relationship for species is determined

Shibutani ST, Saitoh T, Nowag H, Mnz C, Yoshimori T (2015) Autophagy and autophagy-related proteins in the immune system