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Guemez-Gamboa A, Estrada-Snchez AM, Montiel T et al (2011) Activation of NOX2 by the stimulation of ionotropic and metabotropic glutamate receptors contributes to glutamate neurotoxicity in vivo through the production of reactive oxygen species and calpain activation

Blood and urine analysis demonstrated marked elevations in glycine levels

Oxidative stress can damage blood vessels, leading to serious heart problems

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Additionally, tobacco consumption changes the composition of the microbiota in the gut in a way that mitigates intestinal inflammation, and then leads to less misfolding of the protein -Syn in enteric nerves, reducing the risk of PD by minimizing propagation of the protein aggregates to the central nervous system (CNS) (Derkinderen et al., 2014)

Tenzer, S