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Together, these studies show that inhibition of lipogenic pathways protects from MASLD in multiple models with decreased levels of lipogenic genes, and that GSH depletion through Chac1 overexpression recapitulates similar protective effects by broadly downregulating lipogenic genes
PMID 7492947
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The quality assessment revealed that most studies had a low risk of bias or some concerns in various areas
PMID 23451712.
