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This is not only because of the risk of health effects in the long term, but also to ensure IGF-1 receptors return to proper working order following a cycle

Proc Natl Acad Sci USA 108, 14331438, 10.1073/pnas.1014275108 (2011)
Nucleotide sequence divergence and functional constraint in VIP mRNA evolution between human and rat
Nat Med 23:850858 Stumvoll M, Nurjhan N, Perriello G, Dailey G, Gerich JE (1995) Metabolic effects of metformin in non-insulin-dependent diabetes mellitus
Anti-interleukin-15 therapy

The mTOR pathway in the control of protein synthesis
