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Not necessarily

reviewed the evidence as to whether any of the available forms of B12 are superior, and concluded that all forms can be converted to the active methyl- and adenosyl-B12 forms, and that there was not sufficient evidence to suggest that any form was superior in terms of bioavailability, biochemical effects or clinical efficacy

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Copper is an essential trace element involved in normal biological processes, and peptides are used in cosmetic systems as delivery and signaling components