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Another study found that abnormal fluctuations in E2 and ER lead to disruption of glucose homeostasis in the brain

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Climate Change Drives Widespread and Rapid Thermokarst Development in Very Cold Permafrost in the Canadian High Arctic
Esfandyarpour R, Kashi A, Nemat-Gorgani M, Wilhelmy J, Davis RW
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B., Tvrdeic, A., Pavlov, K