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Description
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IGF1 LR3s extended half-life of 20-30 hours allows for once-daily use and sustained receptor start

Pan et al., 2022

[2] Xu B, Yang M, Li Z, Zhang Y, Jiang Z, Guan S, Jiang D

Within the locus coeruleus (a brainstem nucleus in the dorsal pontine tegmentum) the end product of the pathway is norepinephrine

They promoted it for many years and said that it was inert
