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This pathway is tightly regulated by enzymes such as ornithine aminotransferase (OAT) and pyrroline-5-carboxylate reductase (PYCR), which control proline production and, consequently, the rate of collagen deposition [13,14,15,16]

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Meanwhile, SCFAs also suppresses STAT 3 phosphorylation and effectively reduces IL-6/IL-21-mediated Th 17 polarization (Anvar et al., 2024