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Alzheimers Res Ther 16(1):171

A.van der GootA

Aziz GM, Al-Saady AJ, Bedan DS

Promoter methylation analysis of SIRT3, SMARCA5, HTERT and CDH1 genes in aging and alzheimer's disease

DNA methylation can silence genes and repetitive elements through a process which leads to the alteration of chromatin structure

Indeed, the stronger relationship between elevated circulating homocysteine levels and atherothrombotic disease observed in retrospective case-controlled studies than in prospective studies might be explained by the younger average age of subjects sustaining a coronary event in retrospective studies (in the positive study by Wald et al (1998), see the age comparison between retrospective and prospective studies)